'Pope' might not be a term Zagreus is familiar, but High Priest? That does indeed make sense.

"If you're here though...the local gods must have chosen you. I don't really know much about them yet, but I imagine they must have had a reason for doing so. They clearly see something in you, so...perhaps you should give yourself some more credit."

After all, Zagreus might be an immortal god, Prince of the Underworld...but that didn't mean that mortals weren't important too. Their lives might be much briefer, but that didn't mean they left no mark on the world.